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Canberra, Australia 35.28°S · 149.13°E

Systems architect

I create coherence in complex systems.

Operational systems across software, infrastructure, AI and computational science. Proven by published research, defence clients, and shipped platforms.

Joe Bones — Systems architect

J. Bones — Canberra, AUS

3

Papers in Nature & Science

Defence

Built for military contexts

Full-stack

Atoms to applications

1

Discipline, many domains

About

One discipline, many domains.

Different materials — proteins, infrastructure, interfaces, data — held to one standard: coherence that thrives through change.

More about me
01

Research, Data & Science

Atomic-scale structure made continuous with real-world disease. Published in Nature and Science Advances.

02

Systems & Infrastructure

Backends and infrastructure that hold their shape under load and change.

03

Applications & Product

Products that carry that rigour to the person using them, with the safety operational contexts demand.

Now building In development

EndPoint

PhD · Drug-discovery platform

Structural biology arrives fragmented — every structure in its own state, re-prepared by hand. EndPoint creates a structure library, discovers the conformation end-points, and constructs pristine simulation-ready molecular-dynamics systems through one reproducible pipeline.

Configuration is the source of truth, so the same method transfers from lupus and TLR to any receptor. Promising leads surface sooner, on a footing every result can be trusted on.

See it on the projects page
Now building Public soon

BoneShell

Open source · Dev tooling

Dotfiles scatter and drift. BoneShell makes the repo authoritative — one command, and a fresh macOS or Linux machine is identically home. Beautiful. Powerful. Prepared.

One visual palette cascades to every tool; the machines you work across thread into a single chain that AI agents can move along. Configuration becomes CI tested infrastructure — coherence you carry between systems that can adapt with you.

Built to be beautiful, customised to your own flavour, and kept.

See it on the projects page

Projects

The same discipline, different domains.

Platform · CTO MVP

SelfTherapy

Mental-health support across web, iOS and Android — closing the distance between needing care and reaching it. Co-founder & CTO.

Try the app
Platform · Defence MVP

MindCompass

The same support carried into a military context, where continuity of care is hardest to hold.

Try the app
System · Defence

FABHUMS

Bridge structural-health monitoring, deployed to military clients — sensors, hardware and operators on one interface. Contracted Vue.js frontend.

Explore
Research · Nature 2022

TLR7 gain-of-function genetic variation causes human lupus

Structural impact of a gain-of-function mutation in the TLR7 immune receptor as a cause of human lupus — atomic-scale simulation informing real-world disease.

Read paper
Research · Science Adv. 2023

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency

Computational biophysics on the DECTIN-1 immune-system protein as a modifier in CTLA-4 haploinsufficiency.

Read paper
Research · Nature Immunology 2026

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

How 2′-O-methyl-guanosine RNA fragments antagonise the TLR7 and TLR8 receptors to limit autoimmunity.

Read paper

Alongside

If the work resonates, say hello.

It's a practice I keep in the open. Bring a hard problem, a question, or just a conversation.

Start a conversation